Research Leader (DMPK), Cambridge, MA

About the DMPK and Quantitative Pharmacology team

The DMPK and Quantitative Pharmacology team, part of the Preclinical Development group, accelerates the delivery of high quality drug candidates by developing innovative and creative AI-first solutions. By applying our domain expertise and through collaboration with the entirety of our world-class drug discovery disciplines and ML researchers, we ensure that drug-like properties are at the heart of our drug design engine. We shape the development of state-of-the-art ADME and toxicology predictive models. We rethink drug discovery from Hit ID to first-in-human (FIH) trials by optimising the context of use of these models.

 

Your impact

At Isomorphic Labs, DMPK Leads drive the DMPK strategy of drug discovery projects to deliver high quality clinical candidates whilst using and contributing to the optimisation of state-of-the-art computational and AI ADME models. 

As part of the Drug Design and Medical Research team and through close collaboration with the Technology teams, you will be supporting the business alongside world leading AI/ML Drug Design Platform teams. You will collaborate to deliver scientific expertise and strategic direction to drive both improvements in the Platform and apply this to real drug design projects. 

If you are a skilled and ambitious scientist looking to take the next step in your career, joining Isomorphic Labs will lift you out of your comfort zone and provide you with an amazing opportunity for personal growth and development.

 

What you will do 

• Design and implement stage-appropriate DMPK strategies with AI-first approach, integrating quantitative pharmacology and overall project strategies.
• Design screening cascade and mechanistic experiments to support project progression in a data-driven manner.
• Integrate DMPK, PD and toxicological data to extract decision-making information, including dose and safety window predictions.
• Define Quantitative Pharmacology strategy in collaboration with Pharmacology Leads.
• Optimise the use of Iso’s datasets to address fundamental DMPK questions and advance the field.
• Optimise molecule design based on physico-chemistry and biotransformation knowledge in collaboration with Chemistry Leads.
• Maintain knowledge of state-of-the-art technologies and methods to increase confidence in human PK prediction.
• Author DMPK sections of regulatory documents.
• Embrace and champion a culture of inclusion and continuous professional development.

 

Skills and qualifications 

Essential:

• PhD in either Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject.
• 7-10+ years’ professional experience in a DMPK role, operating within a biotech or pharma setting, solving small molecule DMPK-related problems in drug discovery with a track record of working collaboratively to deliver high quality candidates.
• Practical experience developing DMPK and quantitative pharmacology packages to support early clinical development, including authoring and reviewing regulatory documents, ideally in oncology or immunology.
• Experience of partnering closely with Preclinical and Clinical teams.
• In depth knowledge of biotransformation.
• In depth knowledge of PK modelling and scaling of ADME properties.

Nice to have:

• Experience with peptides and other new modalities.
• Advanced knowledge of PK/PD modelling.
• Good understanding of machine learning techniques.
• Familiarity with Python and R.