Senior Research Investigator (In-vitro / Cellular Pharmacology), London

Your impact

Isomorphic labs are seeking exceptional individuals to join an impactful in-vitro pharmacology sub team within our translational science team, working in multidisciplinary ML-based drug discovery medical research.

These roles would be ideal for experienced in-vitro pharmacologists with significant working knowledge of biophysical, biochemical and/or cell-based functional assays who have extensive experience of providing quantitative in-vitro pharmacology expertise within drug discovery projects.

This is an exciting opportunity to work closely with world leading AI, ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions to drive our projects forward. You will play a key role in defining the screening cascades for our drug design projects, advancing our oncology, immunology and partnership portfolios from early drug discovery through to candidate selection and ultimately to clinical phase work.

You will have experience of working broadly across drug discovery projects and have the ability to think originally and critically, knowing when to apply innovative ideas, and think with a beginners' approach.

What you will do

• Design efficient and comprehensive biological screening cascades for a variety of internal and partnered drug design programs.
• Work with CROs to design decision-making experiments, and deliver the highest quality biological data to inform the path to the clinic.
• Work cross-functionally with our Drug Design and Technology teams.

Skills and qualifications

Essential:

• BSc, MSc or PhD in a relevant field of biology.
• Extensive experience in the design and implementation of biological screening cascades applied to drug design projects from hit identification to Candidate Selection phases.
• Deep knowledge of experimental in-vitro pharmacology techniques including biophysical, biochemical and/or cellular assays.
• Experience working with CROs in acquiring and interpreting high quality biological data in a timely manner.
• Dynamic, agile, and flexible individual who can work across many projects, therapeutic areas, and multi-disciplinary teams.
• Effective communication across a broad interdisciplinary team, working with key stakeholders with different skills and backgrounds.

Nice to have:

• Experience in project leadership or leading biology within drug discovery programs, ideally from inception to clinical candidate delivery.
• Worked with Data Science groups in setting up systems for ingestion of biological data.
• Track record of contributing to drug design projects which have then delivered Clinical Candidates.
• Working knowledge of designing and implementing assays and screening cascades for alternative modalities or alternative chemistries e.g peptides or molecular glues.
• General knowledge of machine learning modelling applied to biological systems and drug discovery.
• Experience of target identification, validation and selection approaches.