Senior Technical Program Manager (Preclinical), London

Your impact 

As Isomorphic Labs accelerates its pipeline, we are approaching a critical inflection point: developing capabilities to deliver Iso’s ambition of multiple drug candidates per year. We are looking for a highly tactical and strategic Technical Program Manager to anchor this process.

You will play a pivotal role in operationalising our path to the clinic, managing the complex sequencing of our first IND submissions. You will be the bridge between our scientific breakthroughs and regulatory reality, ensuring that our data management and documentation mature from research-grade to submission-ready standards. This is an opportunity for a "hands on" operator who can manage detailed logistics today, with the scope to grow as our development portfolio scales.

What you will do 

• Drive non-clinical IND needs: You will manage the timeline and sequencing of late-stage discovery including CMC, DMPK, pharmacology and tox reporting to enable successful submission, ensuring no critical path items are missed. You will partner closely with counterparts in our clinical team to ensure non-clinical and clinical aspects of the IND are integrated correctly.
• Program Management: Create and maintain rigorous project plans that monitor sequencing in a highly detailed way. You will track dependencies across multiple workstreams to ensure alignment with submission goals, including working with a network of external vendors and collaborators and managing large budgets.
• Data Management: Play a leading role in the transition of document and data management workflows from general cloud storage (e.g., Google Drive) to submission-ready systems. You will ensure our data integrity and documentation meet the regulatory standards required for development.
• Cross-Functional Coordination: Act as the operational hub for interdisciplinary teams, facilitating seamless communication between scientific teams, technical operations, and regulatory consultants to keep programs on track. 
• Risk Mitigation: Proactively identify and document risks in the pre-clinical phase and devise mitigation strategies in partnership with Program Leads before they impact timelines. 
• Operational Excellence: Partner with the DDMR Leads to refine the operating model for pre-clinical development, helping to establish the world class infrastructure required for future programs.

Skills and qualifications 

Essential:

• You must have a proven track record of managing an IND application process from late discovery/pre-clinical all the way through to submission. 
• Deep experience working at the intersection of discovery and early development; you understand the specific scientific and operational shifts that occur during this transition.
• Experience implementing or managing regulatory-compliant document management systems.  
• Experience working with external vendors and collaborators.
• Experience managing large budgets.
• You have the ability to be "in the weeds" managing complex schedules and logistics, while possessing enough industry experience to provide high-level strategic input on regulatory hurdles.
• Exceptional organisational skills with a mastery of sequencing complex, multi-disciplinary activities.

Nice to have:

• Scientific MSc or PhD in Biology, Chemistry/protein engineering, toxicology or a related discipline.
• Formal program management qualification (e.g., PMP, PRINCE2) 
• Experience in a high-growth Biotech or TechBio environment
• Experience working on multiple modalities (small molecules, biologics, …)